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Techniques such as the wavelet transform proposed by Turkheimer et al.

International Conference on Quantification of Brain Function with PET

Similar records in OSTI. GOV collections:. Full Record Other Related Research. Abstract A description of some of the methods used in neuroreceptor imaging to distinguish changes in receptor availability has been presented in this chapter. Authors: Logan, J. Publication Date: Research Org. Logan, J. United States: N.

Quantification of Brain Function Using PET

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Also since parametric images can provide information beyond that of ROI analysis, improved techniques for generating such images will be important, particularly for ligands requiring more than a one-compartment model. Other availability. Date: Time: Abstract Positron Emission Tomography PET is an imaging technique that allows for in vivo quantification of biochemical and physiological processes in the brain. Following intravenous injection of a radio-labeled ligand and the ensuing PET examination of a subject, kinetic models are often used to estimate parameters of interest. Example of such parameters are binding potential or distribution volume, which are estimates of the availability of receptors in a specific region or volume-element of the brain.


These parameters can then be inserted into statistical models to infer e. In order to detect effects of interest, it is important that the estimation of these parameters is precise, reliable and valid. The aim of this thesis was to evaluate different methods for estimating such parameters, and apply them on clinical data.

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The thesis consists of two different themes. The focus of theme I was the quantification of dopamine receptor in striatum and the cortex, and their relationship to normal and dysfunctional social behavior. Study I and Study II examined the relationship between dopamine D1 receptor availability and self-rated pro and anti-social behavior in healthy subjects. Study I found a positive correlation between striatal D1 receptor availability and Social Desirability, and a negative correlation to Trait Aggression.

Study II did however fail to replicate these results. In Study III, dopamine D2 receptor availability in limbic and cortical regions in patients with social anxiety disorder and healthy controls were compared. Exploratory analyses suggested that patients had higher D2 receptor availability in the lateral and orbitofrontal cortex, although the results warrant replication in a larger sample.

TPC - Iron in PET studies

The level of TSPO in the brain has been hypothesized to function as an index of microglial cell activity, which in turn is believed to be a proxy for immune activation in the central nervous system. Contrary to the hypothesis of elevated microglia activity, patients were found to have lower TSPO levels. Distribution volume ratios and standardized uptakes value ratios, derived using pseudo-reference regions, showed both poor reliability and convergent validity. Study VI carried out a meta-analysis of TSPO in patients with schizophrenia and psychotic disorders compared to healthy controls. Again, contrary to the hypothesis of higher microglia activity, strong evidence was found in favor of patients having lower TSPO levels in both cortical and subcortical regions.