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Xiaojing Ma. The IGF System. Synthetic PPAR agonists have exhibited therapeutic benefits in treating diabetes and cardiovascular diseases. The discovery of PPAR-specific ligands has led to significant advancement in our understanding of the structure of these receptor proteins and the molecular mechanism of their ligand-dependent activation. Herein, we present both recent progress in the functional analysis of these orphan receptors and the confirmation of the PPARs as molecular targets for the development of new medicines to treat human metabolic disease.
Peroxisome Proliferator-Activated Receptors (PPARs)
Keywords: peroxisome proliferator, ppar, nuclear receptor, ppar agonists, ppar-specific. Abstract: The peroxisome proliferator-activated receptor PPAR family of nuclear receptors, a set of three receptor sub-types encoded by distinct genes, function as lipid sensors to regulate a broad range of genes in many metabolically active tissues. Barry G. Shearer and William J. Shahidul Islam. Ovarian Cancer. Sharon Stack. Heat Shock Protein Inhibitors.
ISBN 10: 1627034196
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